Salim R. Rezaie, MD on Twitter: "It's not looking good for the metabolic cocktail (Vitamin C + Thiamine + Corticosteroids) in Septic Shock...IJS Not all trials equal...highest quality evidence --> VITAMINS >
![Conference Presentation: Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock | Critical Care Medicine | JN Learning | AMA Ed Hub Conference Presentation: Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock | Critical Care Medicine | JN Learning | AMA Ed Hub](https://cdn.edhub.ama-assn.org/ama/content_public/multimedia/jpc190010videoa_thumb.jpeg?Expires=1678238349&Signature=bO5gjZPrJTIZRFIu04nrhmHrtP0WYsbQBMi9WfykMJAVzrDlXT3QCnL8mxUFmDOEQ9ts60d7NtcenBUS68ZWeKeprn-H~bl6h0y2M5YAUOjelbL5IoiDwH09s1dqYrgf5qO2NHC4Ech52X~cmS3Oxnpl83UgabP8q1Fm~1d--L8RdT-URGyLy~lFen5-2upgPNIjcA0axtvk1IsbArqdAXYDW-yMFZ-FfFOazEcCzEgxD6gNnou9yaLOyShj9-LR5d3~Ur1uXFU-wtuC-JFOyB4pFjpDmeIGBykQp39Goxb6owWSplLhoPELEGP77~DOXfcV3BlikO6NPTHwiJBnkA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Conference Presentation: Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock | Critical Care Medicine | JN Learning | AMA Ed Hub
![PDF) Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation PDF) Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation](https://i1.rgstatic.net/publication/328590827_Ascorbic_acid_corticosteroids_and_thiamine_in_sepsis_a_review_of_the_biologic_rationale_and_the_present_state_of_clinical_evaluation/links/5bd7c9be92851c6b2798da1a/largepreview.png)
PDF) Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
![PDF] Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid | Semantic Scholar PDF] Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/de73bf6622fd4dffdc1542439111556401e0e738/5-Table1-1.png)
PDF] Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid | Semantic Scholar
AMBOSS - JAMA recently published an article about whether a cocktail of vitamin C, thiamine, and hydrocortisone be given to all patients with septic shock. Scroll down to read the article summary
![CHEST on Twitter: "RCT in #journalCHEST: No reduction in mortality in # sepsis and #septicshock with hydrocortisone, vitamin C and thiamine therapy vs placebo: https://t.co/pg03uYFCjP #CHESTCritCare https://t.co/vDFbYKZkMi" / Twitter CHEST on Twitter: "RCT in #journalCHEST: No reduction in mortality in # sepsis and #septicshock with hydrocortisone, vitamin C and thiamine therapy vs placebo: https://t.co/pg03uYFCjP #CHESTCritCare https://t.co/vDFbYKZkMi" / Twitter](https://pbs.twimg.com/media/Ec59usmX0AERQry.jpg:large)
CHEST on Twitter: "RCT in #journalCHEST: No reduction in mortality in # sepsis and #septicshock with hydrocortisone, vitamin C and thiamine therapy vs placebo: https://t.co/pg03uYFCjP #CHESTCritCare https://t.co/vDFbYKZkMi" / Twitter
![Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial | Critical Care | Full Text Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial | Critical Care | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13054-022-04175-x/MediaObjects/13054_2022_4175_Figa_HTML.png)
Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial | Critical Care | Full Text
![JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn's • St Emlyn's JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn's • St Emlyn's](https://www.stemlynsblog.org/wp-content/uploads/2020/08/JC_-Vitamin-C-Thiamine-and-Steroids-in-Sepsis.png)
JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn's • St Emlyn's
![PDF) ABSTRACT & COMMENTARY ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients PDF) ABSTRACT & COMMENTARY ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients](https://i1.rgstatic.net/publication/344411758_ABSTRACT_COMMENTARY_ORANGES_and_ACTS_Trials_No_Mortality_Benefit_with_Ascorbic_Acid_Thiamine_and_Hydrocortisone_in_Septic_Shock_Patients/links/5f72be7892851c14bc9cf9fd/largepreview.png)
PDF) ABSTRACT & COMMENTARY ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients
![Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation | Critical Care | Full Text Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation | Critical Care | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13054-018-2217-4/MediaObjects/13054_2018_2217_Fig1_HTML.png)
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation | Critical Care | Full Text
![Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study - ScienceDirect Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0012369216625643-gr3.jpg)